Telopeptide

What is CrossLaps?

The CrossLaps assay is specific for an epitope localized in the C-terminal telopeptide of the collagen type I a1 chain (marked in blue in Figure 1). The CrossLaps epitope encompasses 8 amino acids (EKAHDGGR, residues 1204-1211, marked in red) specific for collagen type I [1,2]. The lysine residue (K, 1205) participates in intra- and inter-molecular covalent cross-links (marked with a red line). These cross-links are generated post-translationally in bone by specific enzyme systems and their role it to enhance the rigidity and structural integrity of the collagen fibers in the bone matrix. A common form of cross-links is deoxypyridinoline (DPD) but a number of other cross-links can be found in the CrossLaps® molecule [3].

The peptide bond between the aspartate (Asp) and glycine (Gly) residues (marked in bold) is susceptible to undergo a spontaneous non-enzymatic reaction resulting in the formation of isomerized (α-Asp) linkages [3,4]. This is found only in mature collagen that has been incorporated into the bone matrix.

Read more about our bone marker assays that are divided into pre-clinical and clinical assays:

Pre-clinical assays
Clinical assays

IDS Nordic a/s is committed to the development of diagnostic products for the improved management of patients suffering from bone and cartilage related diseases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, and bone metastasis. We are among the world leaders in the niche field of bone and cartilage diagnostics and have a comprehensive research and development pipeline dedicated to these areas.

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Telopeptide
What is CrossLaps? The CrossLaps assay is specific for an epitope localized in the C-terminal telopeptide of the collagen type I a1 chain (marked in blue in Figure 1). The CrossLaps epitope encompasses 8 amino acids (EKAHDGGR, residues 1204-1211, marked in red) specific for collagen type I [1,2]. The lysine residue (K, 1205) participates in intra- and inter-molecular covalent cross-links (marked with a red line). These cross-links are generated post-translationally in bone by specific enzyme systems and their role it to enhance the rigidity and structural integrity of the collagen fibers in the bone matrix. A common form of cross-links is deoxypyridinoline (DPD) but a number of other cross-links can be found in the CrossLaps® molecule [3]. The peptide bond between the aspartate (Asp) and glycine (Gly) residues (marked in bold) is susceptible to undergo a spontaneous non-enzymatic reaction resulting in the formation of isomerized (α-Asp) linkages [3,4]. This is found only in mature collagen that has been incorporated into the bone matrix. Read more about our bone marker assays that are divided into pre-clinical and clinical assays: Pre-clinical assays Clinical assays...

Bone markers
IDS Nordic a/s promotes a panel of biochemical assays for assessment of bone diseases in in-vitro models, pre-clinical models and clinical studies. Recently we joint partnerships with several biotech companies and suppliers. We act as their distributor for a wide range of biochemical assays and together with our own assays this enable us to provide a complete product range to our customers. Read more about our bone marker assays that are divided into pre-clinical and clinical assays. More information about bone markers ...

Cartilage degradation
Urine Pre-Clinical CartiLaps® ELISA Cat. # 2CAL4000: Collagen type II is the major component of articular cartilage. Cartilage degradation of collagen fibers in articular cartilage is a critical and irreversible event in the pathology of arthritis. This fact, and the importance of collagen type II to the biomechanical properties of cartilage, suggests that collagen type II cartilage degradation is a key event in cartilage damage. Serum Pre-Clinical CartiLaps® ELISA Cat. # 3CAL4000: Collagen type II is the major component of articular cartilage. Cartilage degradation of collagen fibers in articular cartilage is a critical and irreversible event in the pathology of arthritis. This fact, and the importance of collagen type II to the biomechanical properties of cartilage, suggests that collagen type II degradation is a key event in cartilage damage. Read more about the cartilage marker assays that are divided into pre-clinical and clinical assays: Pre-clinical assays Clinical assays...